ÓªÒµ×Éѯ
Öйú£º
Email: marketing@medicilon.com.cn
ÓªÒµ×ÉѯרÏߣº400-780-8018
£¨½öÏÞЧÀÍ×Éѯ£¬ÆäËûÊÂÒËÇ벦´ò´¨É³×ܲ¿µç»°£©
´¨É³×ܲ¿µç»°: +86 (21) 5859-1500
ÍâÑó£º
+1(781)535-1428(U.S.)
0044 7790 816 954 (Europe)
Email:marketing@medicilon.com
KRASÐźŵ碌îÊÇÒ»¸ö¶à°ì·¨µÄÀú³Ì£¬ÐèÒªÊʵ±µÄKRAS·ÒëºóÐÞÊΣ¬Ï¸°ûĤ¶¨Î»ÓëЧӦÂѰ׵ÄÏ໥×÷Óá£
The activation of KRAS signaling is a multi-step process that requires proper KRAS post-translation£¬plasma membrane-localization and interaction with effector proteins.
ÔÚϸ°ûÍâ´Ì¼¤×÷ÓÃÏ£¬´Óʧ»îµÄRAS-GDPµ½¼¤»îµÄRAS-GDPµÄת»¯½øÒ»²½Ôö½øÁ˶àÖÖÐźÅͨ·µÄ¼¤»î£¬°üÀ¨MAPKͨ·¡¢PI3k ͨ·ºÍRal-GEFsͨ·£¬ÆäÖÐÒÔMAPKͨ·µÄÌØÕ÷×îΪÏÔ×Å¡£
In response to extracellular stimuli, the conversion from inactive RAS-GDP to active RAS-GDP further promotes the activation of various signaling pathways, which includes MAPK pathway£¬PI3k pathway and the Ral-GEFs pathway,among them the MAPK pathway is the best characterized.
RAS-GDPÖ±½ÓÓëRAFÂѰ×Á¬Ïµ£¬½«RAF¼¤Ã¸¼Ò×å´Óϸ°ûÖÊÕÐﵽĤÉÏ£¬ÔÚϸ°ûĤÉ϶þ¾Û»¯²¢»î»¯¡£¼¤»îµÄRAFËæºó¶ÔÆäÏÂÓε×Î¼´MEK and ERk¾ÙÐÐһϵÁÐÁ×Ëữ·´Ó¦£¬²¢´«µ¼Éú³¤Ðźš£
RAS-GDP directly binds to RAF protein,recruiting RAF Kinese family from cytoplasm to membranes£¬where they dimerize and become active. The activated RAF subsequently carries out a chain of phospholation reactions to its downstream substrates, MEK and ERk, and propagates the growth signal.
×ðÁú¿Ê±ÖúÁ¦ÐÅŵά¿¹Ö×Áö1ÀàÐÂÒ©XNW14010£¨Ð¡·Ö×ÓKRAS G12CÂѰ׹²¼ÛÁ¬ÏµÒÖÖÆ¼Á£©»ñÅúÁÙ´²