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KRASµÄÐźÅͨ·

2023-12-19
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The activation of KRAS signaling is a multi-step process that requires proper KRAS post-translation£¬plasma membrane-localization and interaction with effector proteins.

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In response to extracellular stimuli, the conversion from inactive RAS-GDP to active RAS-GDP further promotes the activation of various signaling pathways, which includes MAPK pathway£¬PI3k pathway and the Ral-GEFs pathway,among them the MAPK pathway is the best characterized.

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RAS-GDP directly binds to RAF protein,recruiting RAF Kinese family from cytoplasm to membranes£¬where they dimerize and become active. The activated RAF subsequently carries out a chain of phospholation reactions to its downstream substrates, MEK and ERk, and propagates the growth signal.

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