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RAS is a family of GTPase proto-oncogenes, comprising three closely related RAS isoforms:HRAS,KRAS and NRAS.
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KRAS gene is a proto-oncogene that encodes a GTP/GDP-binding protein, that belongs to the GTPase RAS family.
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The KRAS protein acts as molecular switches that cycle between a GDP-bound inactive state and a GTP-bound active state. KRAS protein switches between an inactive to an active form via binding to GTP and GDP respectively¡£
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