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GLP-1 shows numerous actions in different tissues, and a broad therapeutic potential.
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The main actions of GLP-1 are to stimulate insulin secretion and to inhibit glucagon secretion,thereby contributing to limit postprandial glucose excursions.
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GLP-1 also causes weight loss by increasing satiety. In addition, GLP-1 also inhibits gastrointestinal motility and secretion,and thus acts as an enterogastrone and part of the "ileal brake" mechanism.