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Glucagon-like peptide-1£¨GLP-1£©is a 30- or 31-amino-cacid-long peptide hormone.GLP-1 exists in two equally bioactive forms,GLP-1 (7-37 )amide and GLP-1 (7-36) amide.
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GLP-1 is a biological product derived from the post-translational processing of proglucagon,GLP-1 is secreted by the enteroentocrine L cells£¬but also by some neuronal populations in the hindbrain.
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GLP-1 potentiates insulin release and reduces glucagon's concentration in physiological conditions.