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GLP-1 ×÷ÓûúÖÆ

2023-09-26
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GLP-1Á¬ÏµGLP-1R(1)ºó £¬GLP-1RÔÚÒȵº¦Âϸ°ûÖÐżÁªGasÂѰ× £¬¼¤»îÏÙÜÕ»·»¯Ã¸£¨AC£© £¬´ÙʹcAMPÔÚϸ°ûÄÚº¬Á¿Éý¸ß £¬¿É¼¤»îÂѰ׼¤Ã¸A(PKA)ºÍcAMPµ÷ÀíµÄÄñàÑßʺËÜÕËá½»Á÷Òò×Ó2£¨Epac-2£©¡£

After activation by full agonists such as GLP-1,GLP-1R(1)  couples with Gas activates adenolate cyclase(AC),and causes the accumulation of cAMP.With increasing cAMP levels, protein kinase A£¨PKA£© and the exchange protein directly activated by cAMP-2(Epac-2) are also activated.

PKA ºÍ Epac-2 ¿ÉÒԹرÕATPÒÀÀµµÄ¼ØÀë×ÓͨµÀ £¬Ê¹Ï¸°ûĤȥ¼«»¯£»»¹¿ÉÒÔ¼¤»îµçѹÒÀÀµµÄ¸ÆÀë×ÓͨµÀ£¨VDCC£©Ê¹¸ÆÀë×ÓÄÚÁ÷²¢±¬·¢Ðж¯µçλ £¬ÕâЩ;¾¶×îÖÕ¶¼»á´Ì¼¤ÑªÌÇÒÀÀµÐÔÒȵºËصÄÉøÍ¸¡£

PKA and Epac-2  trigger the closure of KATP and KV channels,which depolarizes the cell membrane opens voltage-dependent Calcium channels(VDCC) and causes Calcium influx and the promotion of insulin secretion by the islet beta cells

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